Nitrosigine Breakdown

Posted by Jake ASC on

Nitrosigine Breakdown

Nitrosigine Breakdown


Nitrosigine® can help you enhance performance by providing unique benefits and boosting key factors, regardless of fitness level! Nitrosigine® is a patented complex of bonded arginine and silicon owned by Nutrition21®. To date, Nitrosigine® has 19 studies highlighting its efficacy and its safety achieving “Generally Recognized as Safe” status. This ingredient can take your workout to the next level and enhance performance by promoting blood flow. Enhanced blood flow is important during your workout for pumps, focus and post-workout recovery and muscle growth.




Arginine is an amino acid used by the body to produce nitric oxide however, regular Arginine taken orally is ineffective at doing so, making it impractical to see benefits. Since Nitrosigine® consists of a patented complex of bonded arginine and silicon, we not only see the benefits of arginine but also from silicon. Raising arginine levels in the body leads to increased nitric oxide, which dilates blood vessels and ultimately increases blood flow. Nitrosigine® can relaxe blood vessels (improving blood flow) up to 500% more effectively than consuming Arginine HCL alone. Nitrosigine® also enhances blood silicon levels which strengthens and enhances flexibility of arterial walls, helping with increased blood flow.




Nitrosigine® is also clinically shown to demonstrate significant increases in Kallistatin levels, a blood protein known as a potent vasodilator by 32% , and afamin levels, a blood protein that enhances cognitive function by 46%.



In an in vitro study, Nitrosigine® significantly increased nitric oxide (NO) production over each ingredient tested: Arginine AKG, Agmatine Sulfate, Citrulline Malate, L-Arginine, and Citrulline.




In a clinical study, Nitrosigine® significantly increased nitric oxide (NO) levels in as fast as 15 minutes and as long as 6 hours.




Two studies examining a 14-day dosing protocol highlighted baseline arginine levels and nitric oxide were significantly higher on day 14 than baseline from supplementing with Nitrosigine®.



Increased blood flow is essential to muscle growth. Blood delivers oxygen and nutrients to working muscles, while removing waste products that hinder performance. “The pump” allows for the muscles to stretch and a greater number of capillaries to form. This will lead to the muscles will expand and ultimately increase in size over time.


Check out this powerhouse at 1500mg in our El Jefe PreWorkout!


Nitrosigine® can prime your muscles for the hard work you’re about to put in. Nitrosigine® has been shown to significantly reduce markers of muscle damage from exercise like creatine kinase. Clinical research showed supplementing with Nitrosigine® reduced creatine kinase levels after exercise by 56%.



Nitrosigine® is clinically shown to significantly increase mental acuity and focus within 15 minutes by 33% from a single dose. The study also showed Nitrosigine®’s impact on mental acuity build over time.





The max dose to be used in any study has been 1500mg. This is why we included 1500mg of Nitrosigine® in our El Jefe Stim Pre-workout! It is also important to note that Nitrosigine® improves in effectiveness when used daily over time. Prolonged use further promotes vasodilation and blood vessel flexibility as well as increasing nitric oxide, silicon, and arginine blood levels.


Check out this powerhouse at 1500mg in our El Jefe PreWorkout!



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